Why You Might Feel Low or Depressed on GLP-1 Injections

GLP-1 medications (such as semaglutide or tirzepatide) help with weight loss, blood sugar control, and appetite regulation. While many people feel better on these medications, some notice changes in their mood, including feeling low, flat, or even depressed.

Why This Can Happen

• Brain Chemistry: GLP-1 medications work in areas of the brain that also influence mood.

• Blood Sugar Swings: Rapid changes in glucose can affect energy and emotions.

• Appetite Changes: Food often provides comfort. With less hunger and fewer cravings, you may miss that emotional “reward.”

• Nutrient Intake: Eating less sometimes means less protein, vitamins, and minerals your brain needs to feel good.

• Life Adjustments: Weight loss can bring new changes to body image, routines, or expectations, which may feel overwhelming.

What You Can Do

✔️ Eat balanced meals with protein, healthy fats, and colorful fruits/vegetables to support brain health.

✔️ Stay hydrated and avoid skipping meals, which can worsen fatigue or mood swings.

✔️ Move your body daily (walks, stretching, or light exercise improve mood naturally).

✔️ Support mental health: journal, meditate, or talk with a counselor if you’re struggling.

✔️ Check in regularly with your provider to review your medication, dose, and lab work.

✔️ Stay connected: Talk to friends, family, or support groups so you don’t feel alone.

When to Reach Out Immediately

Contact your provider if you experience:

• Persistent sadness or hopelessness

• Loss of interest in things you enjoy

• Significant fatigue or lack of motivation

• Thoughts of self-harm

  
  

You are not alone — these feelings are important and worth addressing. There are many safe and effective ways to support both your health and your mood.

👉 Remember: GLP-1s are tools. If mood changes show up, it doesn’t mean you have to stop treatment — but it does mean your plan should be adjusted so that your body and mind both feel supported.